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Arts therapy interventions within health care produce positive outcomes for patients, staff and carers, though little rigorous evaluation of these activities is conducted using clinically accepted measures. Similarly, heritage-specific therapeutic interventions offer comparable potential to increase well-being. Although museums and galleries have significant capacity to contribute to health and social care, widespread implementation is impeded by lack of robust clinical data quantifying the impact of such interventions. Measurement scales for psychological well-being, quality of life and health status were reviewed for their suitability to evaluate well-being in hospital patients before and after 30-minute museum object handling sessions. Measures were short-listed using selection criteria of internal and external validity, practicality and sensitivity. Focus on usage in health care, breadth of application, ease of administration and degree of responsiveness informed the choice of optimum measures for preliminary research with female oncology patients (n=40). Findings indicated effectiveness of selected measures (Positive Affect Negative Affect Scale; PANAS and Visual Analogue Scale; VAS) for heritage-specific interventions.