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Frequently, rationally less justifiable arguments and often so called implicit assumptions (which are not explicitly clarified) regarding our conceptions of reality are perhaps an underestimated but crucial factor causing controversial discussions between the representatives of equal and different disciplines. The essay conceptualizes the separation of academic disciplines from a new theoretical viewpoint by looking at the fundamental structures of reality on the level of the roots, not the fruits. Basic assumptions and deeply rooted convictions and conceptions of reality, theories and models in quantum physics, consciousness studies and art may thereby be regarded as a cause for communication problems. Can a wider scope of how to define the foundation of science support the concept of a necessary initiation of a movement towards a more expansive and deliberate synchronization of the separate disciplines into new synthetic combinations of knowledge? The essay speculatively concludes with some central points of how new modes of knowledge production may be envisioned. It includes a perspective on the origin of knowledge with a wider scope that goes beyond the conventional frameworks of scientific and artistic exploration.